SCHEMBL8619296

SCHEMBL8619296

CN(C)CCCc1cc2c(cc1I)CCN2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 9/20 0.38
HRH3 Q9Y5N1 1/20 0.35
DRD2 P14416 1/20 0.35
DRD4 P21917 1/20 0.35
MPO P05164 1/20 0.33
SIGMAR1 Q99720 1/20 0.32
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
CASP1 P29466 1/20 0.31
HTT P42858 1/20 0.31
CASP7 P55210 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
PARP1 P09874 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8658577 0.83 SLC6A4 (0.38) SLC6A4HRH3DRD2DRD4MPO
SCHEMBL8389362 0.81 HTR2A (0.41) SLC6A4HRH3GAA
SCHEMBL7756672 0.79 HRH3 (0.38) SLC6A4HRH3KDM4EALDH1A1LMNA
SCHEMBL8615557 0.74 PARP1 (0.44) SLC6A4HRH3SIGMAR1ALDH1A1TP53
SCHEMBL8621045 0.73 HRH3 (0.37) HRH3DRD2DRD4KDM4EMAPT
SCHEMBL8393003 0.73 NOS1 (0.40) SLC6A4KDM4EALDH1A1LMNATP53
SCHEMBL1294534 0.66 KDM4E (0.38) KDM4EALDH1A1LMNATP53GAA
SCHEMBL14500336 0.66 KDM4E (0.52) HRH3SIGMAR1KDM4EALDH1A1LMNA
SCHEMBL9072587 0.66 SMN1; SMN2 (0.45) DRD2DRD4KDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL5421079 0.65 KDM4E (0.55) HRH3SIGMAR1KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998050346-A2 ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed