Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16713349 | 0.87 | NR1H4 (0.51) | CYP11B1CYP11B2SMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL16713328 | 0.87 | NR1H4 (0.51) | CYP11B1CYP11B2SMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL16713343 | 0.86 | BRD4 (0.53) | SMN1; SMN2HDAC1HDAC6AGTR2ACHE | |
| SCHEMBL16713333 | 0.86 | BRD4 (0.49) | SMN1; SMN2HDAC1HDAC6ACHENR1H4 | |
| SCHEMBL9041879 | 0.84 | CYP11B1 (0.53) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| SCHEMBL8396472 | 0.83 | CYP11B1 (0.67) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| SCHEMBL16713329 | 0.80 | PPARG (0.49) | PPARG | |
| SCHEMBL8394659 | 0.80 | PPARG (0.54) | HDAC1HDAC6TNFEDNRAAGTR2 | |
| SCHEMBL8395491 | 0.80 | PPARG (0.54) | AGTR2ACHEPPARG | |
| SCHEMBL8391700 | 0.80 | PPARG (0.54) | AGTR2ACHEPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |