Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391700 | 0.90 | PPARG (0.54) | PPARGAGTR1AGTR2ACHEDRD2 | |
| SCHEMBL8394659 | 0.90 | PPARG (0.54) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL8394173 | 0.89 | PPARG (0.61) | PPARGAGTR1AGTR2 | |
| SCHEMBL8395988 | 0.88 | DRD2 (0.54) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL8393697 | 0.88 | PPARG (0.63) | PPARGAGTR1AGTR2 | |
| SCHEMBL8393163 | 0.88 | TP53 (0.57) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL8392761 | 0.87 | HDAC1 (0.55) | PPARGAGTR1AGTR2ACHE | |
| SCHEMBL8396641 | 0.87 | MMP7 (0.52) | PPARGAGTR1AGTR2ACHEDRD2 | |
| SCHEMBL8395737 | 0.86 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL8392428 | 0.86 | POLB (0.60) | PPARGAGTR1AGTR2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |