Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 6/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16713349 | 0.93 | NR1H4 (0.51) | NR1H4PPARGACHECYP11B1CYP11B2 | |
| SCHEMBL16713333 | 0.92 | BRD4 (0.49) | NR1H4PPARGACHEHDAC1HDAC6 | |
| SCHEMBL8393383 | 0.87 | CYP11B1 (0.54) | NR1H4PPARGACHECYP11B1CYP11B2 | |
| SCHEMBL16713344 | 0.85 | PPARG (0.69) | PPARG | |
| SCHEMBL16713329 | 0.85 | PPARG (0.49) | PPARG | |
| SCHEMBL16713343 | 0.84 | BRD4 (0.53) | NR1H4ACHEHDAC1HDAC6ALDH1A1 | |
| SCHEMBL28552677 | 0.83 | HCAR3 (0.62) | PPARGACHE | |
| SCHEMBL14120788 | 0.83 | PPARG (0.58) | PPARGACHEHDAC1HDAC6 | |
| SCHEMBL14120280 | 0.81 | PPARG (0.59) | PPARGHDAC1HDAC6 | |
| SCHEMBL14977445 | 0.80 | PPARG (0.47) | PPARGACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9309227-B2 | N-biphenylmethylbenzimidazole modulators of PPARG | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-12 | — | — | US | disclosed |
| US-9309227-B2 | N-biphenylmethylbenzimidazole modulators of PPARG | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-12 | — | — | US | disclosed |
| US-9309227-B2 | N-biphenylmethylbenzimidazole modulators of PPARG | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-12 | — | — | US | disclosed |
| US-20150141464-A1 | N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG | SCRIPPS RESEARCH INSTITUTE, THE | 2015-05-21 | — | — | US | disclosed |
| US-20150141464-A1 | N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG | SCRIPPS RESEARCH INSTITUTE, THE | 2015-05-21 | — | — | US | disclosed |
| US-20150141464-A1 | N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG | SCRIPPS RESEARCH INSTITUTE, THE | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141464-A1 | N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG | CDK5, PPARG, CDK5R1 | NR1H4 211/4885PPARG 2/4885ACHE 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.