Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 8/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396767 | 0.97 | HRH4 (0.49) | HRH4HRH3ACHEEPHX1SIGMAR1 | |
| SCHEMBL8396985 | 0.95 | HRH4 (0.51) | HRH4HRH3ACHEEPHX1SIGMAR1 | |
| SCHEMBL8392734 | 0.95 | HRH4 (0.51) | HRH4HRH3ACHEEPHX1SIGMAR1 | |
| SCHEMBL8393965 | 0.93 | ACHE (0.47) | HRH4HRH3ACHEHDAC3HDAC4 | |
| SCHEMBL8397005 | 0.90 | EPHX1 (0.45) | HRH4HRH3ACHEEPHX1SIGMAR1 | |
| SCHEMBL8944499 | 0.86 | EPHX1 (0.49) | HRH4HRH3ACHEEPHX1SIGMAR1 | |
| SCHEMBL8397097 | 0.85 | EPHX1 (0.51) | HRH4HRH3EPHX1SIGMAR1 | |
| SCHEMBL8396174 | 0.85 | EPHX1 (0.51) | HRH4HRH3EPHX1SIGMAR1 | |
| SCHEMBL8395155 | 0.84 | EPHX1 (0.48) | HRH4HRH3EPHX1SIGMAR1 | |
| SCHEMBL8395535 | 0.82 | HRH4 (0.45) | HRH4HRH3ACHEEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |