SCHEMBL8395014

SCHEMBL8395014

CCOC(OC)Oc1cc(C(O)C#Cc2ccccc2C=O)ccc1C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.30

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.30
CNR2 P34972 2/20 0.30
CNR1 P21554 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8397873 0.87 CNR2 (0.35) FAAHCNR2CNR1
SCHEMBL8397810 0.87 RARB (0.31)
SCHEMBL8435254 0.86 HDAC11 (0.32)
SCHEMBL8568784 0.81 RARA (0.33)
SCHEMBL8690301 0.81 RARA (0.36) FAAHCNR2CNR1
SCHEMBL8432383 0.80 RARA (0.39)
SCHEMBL8435758 0.80 LMNA (0.30)
SCHEMBL8435663 0.78 RARB (0.34) CNR2
SCHEMBL8398155 0.76 CNR2 (0.34) FAAHCNR2CNR1
SCHEMBL8394248 0.76 HDAC11 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5877342-A SKIN DISORDERS; RESPIRATORY SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUIES GALDERMA (FR) 1999-03-02 US claimed
US-5877342-A SKIN DISORDERS; RESPIRATORY SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUIES GALDERMA (FR) 1999-03-02 US disclosed