Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6730322 | 0.97 | DRD2 (0.47) | HTR1AHTR1DHTR1BDRD2CYP1A2 | |
| SCHEMBL34468469 | 0.86 | CYP1A2 (0.48) | CYP1A2CYP2A6LMNAOPRM1OPRD1 | |
| SCHEMBL1628516 | 0.83 | CYP1A2 (0.46) | CYP1A2CYP2A6LMNASLC6A4SLC6A3 | |
| SCHEMBL654668 | 0.82 | DRD2 (0.59) | DRD2SIGMAR1LMNATNFOPRM1 | |
| SCHEMBL8397950 | 0.81 | DRD2 (0.44) | DRD2CYP1A2SIGMAR1CYP3A4CYP2D6 | |
| SCHEMBL8396060 | 0.81 | DRD2 (0.44) | DRD2CYP1A2SIGMAR1CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9529474 | 0.81 | DRD2 (0.58) | DRD2SIGMAR1LMNASLC6A2OPRM1 | |
| SCHEMBL2272581 | 0.81 | DRD2 (0.53) | DRD2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL737743 | 0.80 | OPRM1 (0.57) | DRD2SIGMAR1HTR2CSLC6A2SLC6A3 | |
| SCHEMBL8395822 | 0.79 | TSHR (0.43) | DRD2SLC6A2SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |