Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CEL | P19835 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392445 | 1.00 | NAAA (0.36) | NAAAOPRK1CYP1A2SIGMAR1MAPT | |
| SCHEMBL8396156 | 0.98 | NAAA (0.34) | NAAAOPRK1CYP1A2SIGMAR1MAPT | |
| SCHEMBL8391510 | 0.95 | NAAA (0.31) | NAAAOPRK1 | |
| SCHEMBL8391439 | 0.94 | ACHE (0.31) | — | |
| SCHEMBL8396951 | 0.92 | NAAA (0.37) | NAAAOPRK1CYP1A2SIGMAR1MAPT | |
| SCHEMBL8395467 | 0.92 | NAAA (0.37) | NAAAOPRK1CYP1A2SIGMAR1MAPT | |
| SCHEMBL8396468 | 0.90 | NAAA (0.35) | NAAAOPRK1CYP1A2SIGMAR1MAPT | |
| SCHEMBL8392440 | 0.90 | ACHE (0.36) | NAAACTSDBACE1CEL | |
| SCHEMBL8395229 | 0.90 | ACHE (0.36) | NAAACTSDBACE1CEL | |
| SCHEMBL8392789 | 0.89 | ACHE (0.37) | CTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |