Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 14/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8400226 | 0.96 | HTR1A (0.62) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| Oxalic Acid SCHEMBL7814401 | 0.93 | HTR1A (0.55) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| Oxalic Acid SCHEMBL8397820 | 0.90 | HTR1A (0.60) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL5584644 | 0.89 | HTR1A (0.59) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL8793867 | 0.88 | HTR1A (0.49) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| Oxalic Acid SCHEMBL8400190 | 0.87 | ABCB1 (0.51) | HTR1ASLC6A4ABCB1 | |
| Oxalic Acid SCHEMBL8400124 | 0.87 | DRD2 (0.43) | HTR1ASLC6A4 | |
| SCHEMBL8399026 | 0.86 | ABCB1 (0.55) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL8397985 | 0.86 | HTR1A (0.65) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL8396250 | 0.86 | HTR1A (0.64) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1997048698-A1 | COMPOUNDS HAVING EFFECTS ON SEROTONIN-RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |