Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8395155 | 0.92 | EPHX1 (0.48) | EPHX1SIGMAR1HRH4HRH3EPHX2 | |
| SCHEMBL8393248 | 0.92 | EPHX1 (0.48) | EPHX1SIGMAR1HRH4HRH3EPHX2 | |
| SCHEMBL8394813 | 0.91 | HRH4 (0.48) | EPHX1SIGMAR1HRH4HRH3EPHX2 | |
| SCHEMBL8391354 | 0.91 | HRH4 (0.48) | EPHX1SIGMAR1HRH4HRH3EPHX2 | |
| SCHEMBL8397010 | 0.88 | EPHX1 (0.45) | EPHX1SIGMAR1HRH4HRH3TDP1 | |
| SCHEMBL9998079 | 0.86 | EPHX1 (0.43) | EPHX1SIGMAR1HRH4HRH3KMT2A | |
| SCHEMBL4077144 | 0.83 | TDP1 (0.59) | EPHX1TDP1GAAMEN1KMT2A | |
| SCHEMBL8393965 | 0.83 | ACHE (0.47) | HRH4HRH3ACHEKMT2A | |
| SCHEMBL8391372 | 0.80 | EPHX1 (0.53) | EPHX1SIGMAR1HRH4HRH3EPHX2 | |
| SCHEMBL8393398 | 0.80 | EPHX1 (0.49) | EPHX1SIGMAR1HRH4HRH3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |