Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 10/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392589 | 1.00 | GAA (0.56) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL8394064 | 0.98 | GAA (0.58) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL8391526 | 0.95 | HTR7 (0.54) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL8394591 | 0.91 | GAA (0.52) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL3406334 | 0.80 | GAA (0.58) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL8393842 | 0.76 | GAA (0.62) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL8396704 | 0.76 | GAA (0.62) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL3193960 | 0.75 | GAA (0.96) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL7541549 | 0.75 | GAA (0.96) | GAAMCOLN3HTR7PSEN1PSEN2 | |
| SCHEMBL8393598 | 0.73 | GAA (0.64) | GAAMCOLN3HTR7PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |