Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.71 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973342 | 0.93 | MAOB (0.81) | MAOBEGLN1NPC1RAB9AMAOA | |
| SCHEMBL19835607 | 0.86 | MAOB (0.76) | MAOBEGLN1NPC1RAB9AMAOA | |
| SCHEMBL16887934 | 0.85 | MAOB (0.69) | MAOBEGLN1NPC1RAB9AMAOA | |
| SCHEMBL29262574 | 0.83 | MAOB (0.71) | MAOBEGLN1NPC1RAB9AMAOA | |
| Lazabemide SCHEMBL20769840 | 0.83 | MAOB (1.00) | MAOBEGLN1NPC1RAB9AMAOA | |
| Lazabemide SCHEMBL29710899 | 0.83 | MAOB (1.00) | MAOBEGLN1NPC1RAB9AMAOA | |
| SCHEMBL14329887 | 0.83 | MAOB (0.71) | MAOBEGLN1NPC1RAB9AMAOA | |
| Lazabemide SCHEMBL121998 | 0.83 | MAOB (1.00) | MAOBEGLN1NPC1RAB9AMAOA | |
| SCHEMBL29459609 | 0.83 | MAOB (0.71) | MAOBEGLN1NPC1RAB9AMAOA | |
| Lazabemide SCHEMBL1230476 | 0.82 | MAOB (0.97) | MAOBEGLN1NPC1RAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079583-A1 | SYSTEM PROVIDING CONTROLLED DELIVERY OF GASEOUS CO FOR CARBONYLATION REACTIONS | AARHUS UNIVERSITET (DK) | 2012-06-21 | — | — | WO | disclosed |
| EP-0611774-B1 | Production of amides and peptides without racemization in the presence of catalytic amounts of a N-hydroxy-compound | HOFFMANN LA ROCHE (CH) | 1999-05-26 | — | — | EP | disclosed |
| EP-0582825-B1 | Amidation of pyridines | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| CN-1035873-C | Preparation of amides and peptides | HOFFMANN LA ROCHE (CH) | 1997-09-17 | — | — | CN | disclosed |
| US-5536816-A | Process for producing amides using catalytic amounts of an N-hydroxy compound | HOFFMANN-LA ROCHE INC. (US) | 1996-07-16 | — | — | US | disclosed |
| US-5534635-A | Process for preparing pyridine-2-carboxamides | HOFFMANN-LA ROCHE INC. (US) | 1996-07-09 | — | — | US | disclosed |
| CN-1111237-A | Preparation of amides and peptides | HOFFMANN LA ROCHE (CH) | 1995-11-08 | — | — | CN | disclosed |
| US-5380861-A | Process for preparing pyridine 2-carboxamides | HOFFMANN-LA ROCHE INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0611774-A1 | Production of amides and peptides without racemization in the presence of catalytic amounts of a N-hydroxy-compound | F. HOFFMANN-LA ROCHE AG (CH) | 1994-08-24 | — | — | EP | disclosed |
| EP-0582825-A1 | Amidation of pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-02-16 | — | — | EP | disclosed |
| EP-0385210-A2 | Amidation of pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-05 | — | — | EP | disclosed |
| US-4764522-A | ANTIDEPRESSANT, ANTIPARKINSON DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1988-08-16 | — | — | US | disclosed |