Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397239 | 1.00 | DRD2 (0.38) | DRD2CYP3A4APPCYP2C9CYP2C19 | |
| SCHEMBL8440138 | 0.86 | FFAR4 (0.39) | CYP3A4APPCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL8440137 | 0.86 | FFAR4 (0.39) | CYP3A4APPCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL7753057 | 0.84 | GRM2 (0.39) | CYP3A4APPCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL7753060 | 0.84 | GRM2 (0.39) | CYP3A4APPCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL8397246 | 0.84 | CYP3A4 (0.37) | CYP3A4APPCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL8397245 | 0.84 | CYP3A4 (0.37) | CYP3A4APPCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL7753058 | 0.83 | DRD2 (0.51) | DRD2MEN1KMT2A | |
| SCHEMBL7753063 | 0.83 | DRD2 (0.51) | DRD2MEN1KMT2A | |
| SCHEMBL7771013 | 0.82 | FFAR4 (0.40) | CYP3A4RARBFFAR4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650969-B1 | A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it | SHINETSU CHEMICAL CO (JP) | 1999-05-26 | — | — | EP | disclosed |
| US-5659059-A | Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| EP-0650969-A1 | A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it | Shin-Etsu Chemical Co., Ltd. (JP) | 1995-05-03 | — | — | EP | disclosed |