SCHEMBL7753063

SCHEMBL7753063

CCCCC[Si@H]1CC[C@H](c2ccc(OC)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.51
SPHK1 Q9NYA1 3/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
LMNA P02545 1/20 0.36
RAB9A P51151 1/20 0.36
KDM1A O60341 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
CAMK2A Q9UQM7 1/20 0.35
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7753058 1.00 DRD2 (0.51) DRD2SPHK1ALDH1A1MAPTSMN1; SMN2
SCHEMBL8452873 0.99 DRD2 (0.50) DRD2SPHK1ALDH1A1MAPTSMN1; SMN2
SCHEMBL8452875 0.99 DRD2 (0.50) DRD2SPHK1ALDH1A1MAPTSMN1; SMN2
SCHEMBL8415934 0.90 DRD2 (0.45) DRD2SPHK1ALDH1A1MAPTSMN1; SMN2
SCHEMBL8415936 0.90 DRD2 (0.45) DRD2SPHK1ALDH1A1MAPTSMN1; SMN2
SCHEMBL7757096 0.87 MAPT (0.47) DRD2ALDH1A1MAPTSMN1; SMN2MEN1
SCHEMBL7757100 0.87 MAPT (0.47) DRD2ALDH1A1MAPTSMN1; SMN2MEN1
SCHEMBL9235072 0.84 SPHK1 (0.42) DRD2SPHK1
SCHEMBL9235077 0.84 SPHK1 (0.42) DRD2SPHK1
SCHEMBL8397239 0.83 DRD2 (0.38) DRD2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0718387-B1 A liquid crystal composition and a liquid crystal display element which contains it SHINETSU CHEMICAL CO (JP) 2001-03-14 EP disclosed
US-6004478-A LIQUID CRYSTAL SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-12-21 US disclosed
US-5980778-A STABILITY, COMPATIBILITY SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-11-09 US disclosed
US-5951913-A Liquid crystal compositions comprising silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-09-14 US disclosed
US-5762826-A Liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-06-09 US disclosed
US-5755995-A DISAZO DYES, TRISAZO DYES AND ANTHRAQUINONE DYES WITH LIQUID CRYSTAL POLYMERS SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-05-26 US disclosed
US-5730901-A Silacyclohexane compounds, preparation thereof liquid crystal compositions comprising the same, and liquid crystal devices comprising the composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-03-24 US disclosed
EP-0799878-A1 Liquid crystal compositions and liquid crystal display elements containing same Shin-Etsu Chemical Co., Ltd. (JP) 1997-10-08 EP disclosed
EP-0768361-A1 Liquid crystal composition and liquid crystal display element comprising the same SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-04-16 EP disclosed
EP-0732335-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-09-18 EP disclosed
EP-0718387-A1 A liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-26 EP disclosed