Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397348 | 0.94 | ALDH1A1 (0.46) | ALDH1A1RECQLNOS2PKMKDM4E | |
| SCHEMBL16094114 | 0.92 | ALDH1A1 (0.47) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL8401132 | 0.88 | ALDH1A1 (0.48) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL8397322 | 0.86 | ALDH1A1 (0.46) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL8401123 | 0.86 | RECQL (0.46) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL8401124 | 0.86 | ALDH1A1 (0.49) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL8397355 | 0.84 | ALDH1A1 (0.47) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL8397361 | 0.84 | ALDH1A1 (0.44) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL16122352 | 0.83 | ALDH1A1 (0.56) | ALDH1A1RECQLPKMKDM4EMAPK1 | |
| SCHEMBL8936752 | 0.83 | NOS2 (0.48) | ALDH1A1RECQLNOS2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663899-B1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | UNIV MARYLAND (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0919538-A1 | Substituted kynurenines, a process for their preparation, and use as medicaments | THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5786508-A | ENZYME INHIBITOR; COGNITION ACTIVATOR | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-07-28 | — | — | US | disclosed |
| US-5708030-A | COGNITION ACTIVATORS, PERINATAL BRAIN DISORDERS | UNIVERSITY OF MARYLAND (US) | 1998-01-13 | — | — | US | disclosed |
| US-5519055-A | ENZYME INHIBITORS | UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0663899-A4 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS. | UNIV MARYLAND (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0663899-A1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1995-07-26 | — | — | EP | disclosed |
| WO-1995004714-A1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1995-02-16 | — | — | WO | disclosed |