Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.60 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.60 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394940 | 0.83 | HSD17B10 (0.51) | GRM8GRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8395045 | 0.83 | GRIN2D (0.50) | GRM8GRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8398658 | 0.83 | ALDH1A1 (0.51) | GRM8GRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8398452 | 0.79 | TDP1 (0.51) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7465528 | 0.78 | ALDH1A1 (0.55) | GRM8GRM4GPR35ALDH1A1TP53 | |
| SCHEMBL8398611 | 0.78 | POLB (0.51) | GRM8GRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL51384 | 0.76 | ALDH1A1 (0.56) | GRM8GRM4GPR35ALDH1A1TP53 | |
| SCHEMBL1647499 | 0.76 | ALDH1A1 (0.56) | GRM8GRM4GPR35ALDH1A1TP53 | |
| SCHEMBL4089285 | 0.76 | GRM8 (1.00) | GRM8GRM4 | |
| SCHEMBL8394979 | 0.75 | PDE7A (0.56) | GRM8GRM4GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994563-A | THIOPHENE DERIVATIVES, IMMUNOSUPPRESSANTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-11-30 | — | — | US | disclosed |