Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397473 | 0.83 | GRM8 (0.60) | ALDH1A1TSHRGRIN2DGRIN3BGRIN1 | |
| SCHEMBL18993967 | 0.82 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCYP3A4HTT | |
| SCHEMBL8394940 | 0.81 | HSD17B10 (0.51) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8395045 | 0.81 | GRIN2D (0.50) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8397454 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL8398452 | 0.81 | TDP1 (0.51) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11317580 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRCYP3A4HTT | |
| SCHEMBL8395016 | 0.79 | TBXA2R (0.49) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL8398440 | 0.79 | GRIN2D (0.41) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL8394976 | 0.77 | PTGES (0.52) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994563-A | THIOPHENE DERIVATIVES, IMMUNOSUPPRESSANTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-11-30 | — | — | US | disclosed |