Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397975 | 1.00 | POLB (0.36) | POLBMAPTHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL1576184 | 0.82 | CA14 (0.40) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL701746 | 0.82 | POLB (0.38) | POLBMAPTHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL324715 | 0.82 | POLB (0.38) | POLBMAPTHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL324716 | 0.82 | POLB (0.38) | POLBMAPTHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL8400666 | 0.80 | MMP1 (0.38) | CA1CA2CXCR2MMP1MMP2 | |
| SCHEMBL29205828 | 0.80 | MMP1 (0.38) | CA1CA2CXCR2MMP1MMP2 | |
| SCHEMBL9773131 | 0.79 | MMP8 (0.43) | POLBMAPTHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL31153798 | 0.79 | CA12 (0.34) | CA12CA1CA2CXCR2 | |
| SCHEMBL5551942 | 0.79 | CA12 (0.34) | CA12CA1CA2CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918757-A1 | 8-HYDROCARBYL SUBSTITUTED BENZODIZOCINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN KINASE C (=PKC) MODULATORS | GEORGETOWN UNIVERSITY (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1997043268-A1 | 8-HYDROCARBYL SUBSTITUTED BENZODIZOCINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN KINASE C (=PKC) MODULATORS | GEORGETOWN UNIVERSITY (US) | 1997-11-20 | — | — | WO | disclosed |