Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FABP7 | O15540 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506591 | 1.00 | MMP3 (0.54) | MMP3MMP8MEN1KMT2AGAA | |
| SCHEMBL8398009 | 1.00 | MMP3 (0.54) | MMP3MMP8MEN1KMT2AGAA | |
| SCHEMBL10738463 | 0.88 | MMP3 (0.46) | MMP3MMP8MEN1KMT2AGAA | |
| SCHEMBL10796947 | 0.85 | MMP3 (0.47) | MMP3MMP8MEN1KMT2AGAA | |
| SCHEMBL8397535 | 0.83 | TFPI2 (0.51) | MMP3MMP8MEN1KMT2AMAPT | |
| SCHEMBL8397538 | 0.83 | TFPI2 (0.51) | MMP3MMP8MEN1KMT2AMAPT | |
| SCHEMBL8397537 | 0.83 | TFPI2 (0.51) | MMP3MMP8MEN1KMT2AMAPT | |
| SCHEMBL8401362 | 0.80 | MAPT (0.47) | MEN1KMT2AGAAMAPTTSHR | |
| SCHEMBL4822683 | 0.80 | MAPT (0.47) | MEN1KMT2AGAAMAPTTSHR | |
| SCHEMBL8401366 | 0.80 | MAPT (0.47) | MEN1KMT2AGAAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869518-A | USEFUL IN THE TREATMENT OF OBESITY AND HYPERGLYCEMIA | SYNTHELABO (FR) | 1999-02-09 | — | — | US | disclosed |
| US-4642315-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4587234-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1986-05-06 | — | — | US | disclosed |
| US-4499079-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-12 | — | — | US | disclosed |