Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NR1D1 | P20393 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8401362 | 1.00 | MAPT (0.47) | MAPTPKMTSHRNR1D1RAB9A | |
| SCHEMBL4822683 | 1.00 | MAPT (0.47) | MAPTPKMTSHRNR1D1RAB9A | |
| SCHEMBL14193309 | 0.93 | NR1D1 (0.48) | MAPTPKMTSHRNR1D1RAB9A | |
| SCHEMBL4815395 | 0.93 | NR1D1 (0.48) | MAPTPKMTSHRNR1D1RAB9A | |
| SCHEMBL8397951 | 0.86 | ALDH1A1 (0.47) | MAPTPKMTSHRNR1D1RAB9A | |
| SCHEMBL8397958 | 0.86 | ALDH1A1 (0.47) | MAPTPKMTSHRNR1D1RAB9A | |
| SCHEMBL8397955 | 0.86 | ALDH1A1 (0.47) | MAPTPKMTSHRNR1D1RAB9A | |
| SCHEMBL14193303 | 0.83 | NR1D1 (0.43) | MAPTPKMTSHRNR1D1KDM4E | |
| SCHEMBL8399607 | 0.83 | FABP7 (0.50) | TSHRRAB9AALDH1A1GAAHPGD | |
| SCHEMBL10738463 | 0.81 | MMP3 (0.46) | MAPTMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365061-B2 | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365061-B2 | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-04-29 | — | — | US | disclosed |
| US-5869518-A | USEFUL IN THE TREATMENT OF OBESITY AND HYPERGLYCEMIA | SYNTHELABO (FR) | 1999-02-09 | — | — | US | disclosed |