Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671345 | 0.83 | KLK7 (0.52) | KLK7FTOKDM4EALDH1A1MAPT | |
| Bisnafide SCHEMBL9135739 | 0.77 | FTO (0.61) | FTOKDM4EMAPTKMT2AMEN1 | |
| Bisnafide SCHEMBL29617562 | 0.77 | FTO (0.61) | FTOKDM4EMAPTKMT2AMEN1 | |
| Bisnafide SCHEMBL9135370 | 0.77 | FTO (0.61) | FTOKDM4EMAPTKMT2AMEN1 | |
| Bisnafide SCHEMBL9136305 | 0.77 | FTO (0.61) | FTOKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL8395426 | 0.77 | SIRT1 (0.65) | KLK7FTOALDH1A1MAPTHPGD | |
| Bisnafide SCHEMBL9136683 | 0.77 | FTO (0.61) | FTOKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL9238619 | 0.76 | FTO (0.60) | FTOKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL9348633 | 0.76 | FTO (0.60) | FTOKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL9352511 | 0.76 | FTO (0.60) | FTOKDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981753-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-09 | — | — | US | disclosed |
| US-5616589-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1997-04-01 | — | — | US | disclosed |