Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD4 | Q15561 | 15/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.46 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.46 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624730 | 0.74 | IDH1 (0.43) | TEAD4KDM4EGAAPOLBSMN1; SMN2 | |
| SCHEMBL8396685 | 0.73 | KDM4E (0.60) | TEAD4KDM4EGAAPOLBSMN1; SMN2 | |
| SCHEMBL16421044 | 0.72 | TEAD4 (0.52) | TEAD4KDM4EGAAPOLBSMN1; SMN2 | |
| SCHEMBL6195613 | 0.71 | TEAD4 (0.66) | TEAD4KDM4EGAATEAD1TEAD2 | |
| SCHEMBL3337458 | 0.70 | KDM4E (0.65) | TEAD4KDM4EGAAPOLBSMN1; SMN2 | |
| SCHEMBL20601510 | 0.70 | TEAD4 (0.47) | TEAD4TEAD1TEAD2TEAD3 | |
| SCHEMBL20601560 | 0.69 | HDAC3 (0.47) | TEAD4TEAD1TEAD2TEAD3 | |
| SCHEMBL20601552 | 0.69 | HDAC3 (0.47) | TEAD4TEAD1TEAD2TEAD3 | |
| SCHEMBL20624411 | 0.69 | HDAC3 (0.47) | TEAD4TEAD1TEAD2TEAD3 | |
| SCHEMBL20624406 | 0.69 | HDAC3 (0.47) | TEAD4TEAD1TEAD2TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962480-A | CONTAINING PYRAN-4-ONE OR PYRID-4-ONE RING | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | claimed |
| US-5962480-A | CONTAINING PYRAN-4-ONE OR PYRID-4-ONE RING | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| EP-0838220-A1 | DRUG FOR AMELIORATING BRAIN DISEASES | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 1998-04-29 | — | — | EP | disclosed |