Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13785535 | 0.71 | KDM4E (0.40) | KDM4EALDH1A1LMNANPC1GAA | |
| SCHEMBL1072568 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1LMNANPC1GAA | |
| SCHEMBL10298155 | 0.65 | KDM4E (0.36) | KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL14950267 | 0.65 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNANPC1GAA | |
| SCHEMBL10798452 | 0.64 | KDM4E (0.50) | KDM4EALDH1A1LMNANPC1GAA | |
| SCHEMBL2815843 | 0.63 | TSHR (0.38) | KDM4EALDH1A1LMNANPC1TSHR | |
| SCHEMBL10298199 | 0.62 | KDM4E (0.38) | KDM4EALDH1A1LMNANPC1GAA | |
| Adamantane SCHEMBL29229320 | 0.60 | LMNA (0.40) | LMNATSHR | |
| Adamantane SCHEMBL1527414 | 0.59 | CYP2C9 (0.46) | LMNATSHR | |
| Adamantane SCHEMBL12761 | 0.59 | CYP2C9 (0.46) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994552-A | Process for the production of substituted thiazoline-dioxetan substrates and use thereof | ROCHE DIAGNOSTICS GMBH (DE) | 1999-11-30 | — | — | US | claimed |
| US-5994552-A | Process for the production of substituted thiazoline-dioxetan substrates and use thereof | ROCHE DIAGNOSTICS GMBH (DE) | 1999-11-30 | — | — | US | disclosed |
| US-5712106-A | Process for the production of substituted thiazolin-dioxetan substrates and use thereof | BOEHRINGER MANNHEIM GMBH (DE) | 1998-01-27 | — | — | US | disclosed |
| US-5455357-A | Substituted thiazoline-dioxetan substrates, process for the production and use | BOEHRINGER MANNHEIM GMBH (DE) | 1995-10-03 | — | — | US | disclosed |
| EP-0591489-A1 | SUBSTITUTED THIAZOLINE-DIOXETANE-SUBSTRATES, PROCESS FOR PRODUCING THE SAME AND THEIR USE | BOEHRINGER MANNHEIM GMBH (DE) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993020083-A1 | SUBSTITUTED THIAZOLINE-DIOXETANE-SUBSTRATES, PROCESS FOR PRODUCING THE SAME AND THEIR USE | BOEHRINGER MANNHEIM GMBH (DE) | 1993-10-14 | — | — | WO | disclosed |