Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 19/20 | 0.67 |
| ▸ | HTR1B | P28222 | 17/20 | 0.67 |
| ▸ | HTR1A | P08908 | 16/20 | 0.67 |
| ▸ | HTR2C | P28335 | 8/20 | 0.67 |
| ▸ | HTR2A | P28223 | 8/20 | 0.67 |
| ▸ | HTR6 | P50406 | 6/20 | 0.67 |
| ▸ | HTR7 | P34969 | 2/20 | 0.67 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22411115 | 0.83 | HTR1A (0.79) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8402123 | 0.83 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL14734295 | 0.82 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8759779 | 0.81 | HTR1A (1.00) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8704883 | 0.81 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL7525124 | 0.81 | HTR1D (0.66) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8122186 | 0.81 | MEN1 (0.60) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8705195 | 0.81 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8705402 | 0.81 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8663635 | 0.81 | HTR1A (0.76) | HTR1DHTR1BHTR1AHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5905080-A | Amide and urea derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-05-18 | — | — | US | claimed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| US-5905080-A | Amide and urea derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-05-18 | — | — | US | disclosed |