Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.37 |
| ▸ | BRAP | Q7Z569 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | USP16 | Q9Y5T5 | 1/20 | 0.37 |
| ▸ | USP3 | Q9Y6I4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399110 | 0.90 | ALDH1A1 (0.39) | AKR1B1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL8396244 | 0.88 | AKR1B1 (0.45) | AKR1B1ALDH1A1KDM4EPOLBHDAC6 | |
| SCHEMBL8400221 | 0.87 | AKR1B1 (0.43) | AKR1B1POLBHDAC6GAAPAX8 | |
| SCHEMBL8399303 | 0.85 | AKR1B1 (0.43) | AKR1B1POLBHDAC6TSHRGAA | |
| SCHEMBL8398174 | 0.85 | AKR1B1 (0.43) | AKR1B1ALDH1A1POLBHDAC6GAA | |
| SCHEMBL8396110 | 0.85 | AKR1B1 (0.41) | AKR1B1ALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL8400252 | 0.85 | AKR1B1 (0.41) | AKR1B1ALDH1A1POLBHDAC6TSHR | |
| SCHEMBL8398067 | 0.84 | AKR1B1 (0.46) | AKR1B1ALDH1A1POLBHDAC6TSHR | |
| SCHEMBL8396279 | 0.83 | USP2 (0.40) | AKR1B1ALDH1A1POLBTSHRGAA | |
| SCHEMBL8399147 | 0.81 | MTNR1A (0.39) | AKR1B1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647636-B1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | SENJU PHARMA CO (JP) | 1999-06-09 | — | — | EP | disclosed |
| US-5532257-A | ENZYME INHIBITOR | SENJU PHARMACEUTICAL CO., LTD (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0647636-A1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | Senju Pharmaceutical Co., Ltd. (JP) | 1995-04-12 | — | — | EP | disclosed |