Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FOS | P01100 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396925 | 0.89 | CYP4F2 (0.47) | ALDH1A1KDM4ETSHRSMN1; SMN2CYP4F2 | |
| SCHEMBL8395191 | 0.85 | FOS (0.48) | ALDH1A1KDM4ETSHRSMN1; SMN2CYP4F2 | |
| SCHEMBL7726224 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRSMN1; SMN2KMT2A | |
| SCHEMBL9589692 | 0.77 | HSP90AA1 (0.55) | ALDH1A1KDM4ETSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL4139836 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRSMN1; SMN2KMT2A | |
| SCHEMBL13447383 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRSMN1; SMN2KMT2A | |
| SCHEMBL16682717 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4ETSHRSMN1; SMN2KMT2A | |
| SCHEMBL9589351 | 0.75 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL4513057 | 0.74 | SMN1; SMN2 (0.44) | ALDH1A1KDM4ETSHRSMN1; SMN2CYP4F2 | |
| SCHEMBL4512178 | 0.74 | KDM4E (0.58) | ALDH1A1KDM4ETSHRSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |