Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GCK | P35557 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839929 | 1.00 | RAB9A (0.48) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL839502 | 0.90 | RAB9A (0.55) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL839591 | 0.90 | RAB9A (0.55) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL838748 | 0.90 | RAB9A (0.55) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL838266 | 0.87 | RAB9A (0.53) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL838265 | 0.87 | RAB9A (0.53) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL840526 | 0.87 | RAB9A (0.45) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL840527 | 0.87 | RAB9A (0.45) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL1848056 | 0.87 | RAB9A (0.45) | RAB9AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL839153 | 0.84 | GCK (0.43) | GCKKCNH2HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | GCK, GCKR, GPR119 | RAB9A 3239/4885MAPT 3944/4885KMT2A 4136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.