SCHEMBL8399325

SCHEMBL8399325

CCCCCC=CC(=O)N[C@@H](CCSC)C(=O)OC

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.47
CYP2C9 P11712 1/20 0.47
TAS1R3 Q7RTX0 3/20 0.46
TAS1R1 Q7RTX1 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
TSHR P16473 1/20 0.44
ALDH1A1 P00352 1/20 0.43
GAA P10253 1/20 0.41
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
HTT P42858 1/20 0.40
USP2 O75604 1/20 0.40
PNLIP P16233 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C19 P33261 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8399320 1.00 HDAC2 (0.47) HDAC2CYP2C9TAS1R3TAS1R1L3MBTL1
SCHEMBL8400344 0.87 SLC6A5 (0.46) HDAC2TAS1R3TAS1R1ALDH1A1USP2
SCHEMBL8400342 0.87 SLC6A5 (0.46) HDAC2TAS1R3TAS1R1ALDH1A1USP2
SCHEMBL18796609 0.86 SLC6A5 (0.48) HDAC2TAS1R3TAS1R1
SCHEMBL6562051 0.86 SLC6A5 (0.48) HDAC2TAS1R3TAS1R1
SCHEMBL18796610 0.86 SLC6A5 (0.48) HDAC2TAS1R3TAS1R1
SCHEMBL28372668 0.82 SLC6A5 (0.54) HDAC2CYP2C9TSHRALDH1A1
SCHEMBL28372667 0.82 SLC6A5 (0.54) HDAC2CYP2C9TSHRALDH1A1
SCHEMBL701038 0.80 NOS3 (0.50) TAS1R3TAS1R1CNR1CNR2
SCHEMBL701037 0.80 NOS3 (0.50) TAS1R3TAS1R1CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0666738-B1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 1999-06-09 EP disclosed
EP-0666738-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE. MERCK & CO INC (US) 1996-05-22 EP disclosed
US-5504212-A Inhibitors of farnesyl-protein transferase MERCK & CO., INC. (US) 1996-04-02 US disclosed
EP-0666738-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO. INC. (US) 1995-08-16 EP disclosed
WO-1994009766-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1994-05-11 WO disclosed