Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397807 | 0.86 | SMN1; SMN2 (0.35) | NOTUMRAPGEF3 | |
| SCHEMBL8553570 | 0.85 | NOTUM (0.34) | NOTUMRAPGEF3TRPA1SCN5ASCN9A | |
| SCHEMBL8556443 | 0.83 | NOTUM (0.33) | NOTUMTRPA1SCN5ASCN9A | |
| SCHEMBL8556749 | 0.77 | NOTUM (0.35) | NOTUMTRPA1SCN5ASCN9ADHODH | |
| SCHEMBL8554641 | 0.76 | NOTUM (0.35) | NOTUMTRPA1SCN5ASCN9ADHODH | |
| SCHEMBL8551496 | 0.75 | NOTUM (0.34) | NOTUMTRPA1SCN5ASCN9ADHODH | |
| SCHEMBL8398602 | 0.74 | SMN1; SMN2 (0.37) | RAPGEF3 | |
| SCHEMBL8399379 | 0.74 | NOTUM (0.36) | NOTUMRAPGEF3TRPA1SCN5ASCN9A | |
| SCHEMBL8401038 | 0.74 | SMN1; SMN2 (0.35) | NOTUM | |
| SCHEMBL8556302 | 0.74 | KMT2A (0.34) | DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918756-A1 | PARASITICIDAL PYRAZOLES | Pfizer Limited (GB) | 1999-06-02 | — | — | EP | claimed |
| WO-1998004530-A1 | PARASITICIDAL PYRAZOLES | PFIZER LIMITED (GB) | 1998-02-05 | — | — | WO | claimed |