Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GABRP | O00591 | 3/20 | 0.35 |
| ▸ | GABRD | O14764 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.35 |
| ▸ | GABRE | P78334 | 3/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398602 | 0.88 | SMN1; SMN2 (0.37) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8401038 | 0.88 | SMN1; SMN2 (0.35) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8556302 | 0.87 | KMT2A (0.34) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8399396 | 0.86 | NOTUM (0.36) | NOTUMRAPGEF3 | |
| SCHEMBL8554142 | 0.86 | SHMT1 (0.32) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8554269 | 0.84 | GABRP (0.34) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8554009 | 0.84 | GABRP (0.34) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8553238 | 0.82 | AR (0.33) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7970750 | 0.82 | GABRP (0.33) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8401921 | 0.80 | GAA (0.33) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918756-A1 | PARASITICIDAL PYRAZOLES | Pfizer Limited (GB) | 1999-06-02 | — | — | EP | claimed |
| WO-1998004530-A1 | PARASITICIDAL PYRAZOLES | PFIZER LIMITED (GB) | 1998-02-05 | — | — | WO | claimed |
| EP-0918756-A1 | PARASITICIDAL PYRAZOLES | Pfizer Limited (GB) | 1999-06-02 | — | — | EP | disclosed |
| EP-0871617-A1 | PARASITICIDAL COMPOUNDS | PFIZER INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1998004530-A1 | PARASITICIDAL PYRAZOLES | PFIZER LIMITED (GB) | 1998-02-05 | — | — | WO | disclosed |
| WO-1997007102-A1 | PARASITICIDAL COMPOUNDS | PFIZER INC (US) | 1997-02-27 | — | — | WO | disclosed |