SCHEMBL8399406

SCHEMBL8399406

CNC(=O)/C(=N/OC)c1ccccc1COc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.63
CAPN1 P07384 1/20 0.43
TSHR P16473 2/20 0.40
HSD17B10 Q99714 2/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPK10 P53779 1/20 0.40
KDM4E B2RXH2 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
PTPRC P08575 1/20 0.40
PTPN1 P18031 1/20 0.40
OPRL1 P41146 1/20 0.39
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
PPARG P37231 1/20 0.38
USP2 O75604 1/20 0.37
MAPT P10636 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8369854 1.00 HIF1A (0.63) HIF1ACAPN1TSHRHSD17B10ALDH1A1
SCHEMBL8369852 1.00 HIF1A (0.63) HIF1ACAPN1TSHRHSD17B10ALDH1A1
SCHEMBL8371676 0.93 HIF1A (0.55) HIF1AALDH1A1
SCHEMBL8978434 0.93 HIF1A (0.55) HIF1AALDH1A1
SCHEMBL8371678 0.93 HIF1A (0.55) HIF1AALDH1A1
SCHEMBL8096251 0.91 HIF1A (0.56) HIF1AALDH1A1OPRL1HPGDMAPT
SCHEMBL8096246 0.91 HIF1A (0.56) HIF1AALDH1A1OPRL1HPGDMAPT
SCHEMBL8369944 0.91 HIF1A (0.56) HIF1AALDH1A1OPRL1HPGDMAPT
SCHEMBL8370635 0.91 HIF1A (0.54) HIF1AALDH1A1SMN1; SMN2PTPRCPTPN1
SCHEMBL8370637 0.91 HIF1A (0.54) HIF1AALDH1A1SMN1; SMN2PTPRCPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2311321-A2 Insecticide on the basis of neonicotinoids and selected strobilurins Bayer CropScience AG (DE) 2011-04-20 EP disclosed
EP-2301354-A2 Insecticide on the basis of neonicotinoids and selected strobilurins Bayer CropScience AG (DE) 2011-03-30 EP disclosed
EP-2301355-A2 Insecticides based on nicotinoides and specific strobilurines Bayer CropScience AG (DE) 2011-03-30 EP disclosed
EP-2127523-A2 Insecticide on the basis of neonicotinoids and selected strobilurins Bayer CropScience AG (DE) 2009-12-02 EP disclosed
US-20080274882-A1 Insecticides Based on Selected Neonicotinoids and Strobilurins BAYER CROPSCIENCE AG (DE) 2008-11-06 US disclosed
US-20080274882-A1 Insecticides Based on Selected Neonicotinoids and Strobilurins BAYER CROPSCIENCE AG (DE) 2008-11-06 US disclosed
EP-0644183-B1 Process of producing N-alkylacetamides SHIONOGI & CO (JP) 1999-06-02 EP disclosed
EP-0658541-B1 PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE SHIONOGI & CO (JP) 1998-05-20 EP disclosed
EP-0629609-B1 Process for the preparation of Alkoxyiminoacetamide derivatives and an intermediate therefor SHIONOGI & CO (JP) 1996-12-04 EP disclosed
EP-0398692-B1 Alkoxyiminoacetamide derivatives and their use as fungicides SHIONOGI & CO (JP) 1996-08-21 EP disclosed
US-5510506-A Process for producing carboxylic acid derivatives SHIONOGI & CO., LTD. (JP) 1996-04-23 US disclosed
US-5498792-A Process of producing N-alkylacetamides SHIONOGI & CO., LTD. (JP) 1996-03-12 US disclosed
EP-0658541-A1 PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE SHIONOGI & CO., LTD. (JP) 1995-06-21 EP disclosed
US-5401877-A Agricultural fungicide SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1995-03-28 US disclosed
EP-0644183-A2 Process of producing N-alkylacetamides SHIONOGI & CO., LTD. (JP) 1995-03-22 EP disclosed
EP-0629609-A1 Process for the preparation of Alkoxyiminoacetamide derivatives and an intermediate therefor SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1994-12-21 EP disclosed
US-5371223-A Controlling phytopathogens SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1994-12-06 US disclosed
US-5371222-A Intermediates SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1994-12-06 US disclosed
US-5185342-A ALKOXYIMINOACETAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1993-02-09 US disclosed
EP-0398692-A2 Alkoxyiminoacetamide derivatives and their use as fungicides SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1990-11-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080274882-A1 Insecticides Based on Selected Neonicotinoids and Strobilurins STMN2, STMN1, DDX6 HIF1A 4622/4885CAPN1 690/4885TSHR 2997/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.