Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16907818 | 0.94 | ANO1 (0.33) | ANO1 | |
| SCHEMBL16907817 | 0.89 | — | — | |
| SCHEMBL5143779 | 0.85 | DPP4 (0.35) | DPP4ANO1HDAC3HDAC1HDAC2 | |
| SCHEMBL852232 | 0.81 | HDAC3 (0.37) | DPP4ANO1HDAC3HDAC1HDAC2 | |
| SCHEMBL8684589 | 0.81 | ANO1 (0.37) | DPP4ANO1HDAC3HDAC1HDAC2 | |
| SCHEMBL11336001 | 0.79 | ALDH1A1 (0.35) | DPP4ANO1HDAC3HDAC1HDAC2 | |
| SCHEMBL11341028 | 0.79 | ALDH1A1 (0.35) | DPP4ANO1HDAC3HDAC1HDAC2 | |
| SCHEMBL18793892 | 0.78 | CYP2C9 (0.35) | DPP4ANO1LMNAALDH1A1POLB | |
| SCHEMBL19666657 | 0.78 | ALDH1A1 (0.35) | DPP4ANO1HDAC3HDAC1HDAC2 | |
| SCHEMBL24974708 | 0.78 | LMNA (0.49) | DPP4ANO1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0711283-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| WO-1995003281-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1995-02-02 | — | — | WO | disclosed |
| CN-1074903-A | The six hydrogen azepine ketone and the tetrahydro benzo azepine ketone that replace | PFIZER (US) | 1993-08-04 | — | — | CN | disclosed |