Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31723115 | 0.88 | MAOB (0.61) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL11262567 | 0.87 | ALDH1A1 (0.48) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL29156442 | 0.84 | NPC1 (0.54) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL10900438 | 0.80 | ALDH1A1 (0.54) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL29630236 | 0.80 | SIRT1 (0.66) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL3377499 | 0.80 | SIRT1 (0.66) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL18936167 | 0.79 | MAOB (0.49) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL6614160 | 0.79 | KDM4E (0.52) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL29933483 | 0.79 | KDM4E (0.52) | NPC1RAB9ALMNAMAPTNFKB1 | |
| SCHEMBL10898831 | 0.79 | MAOB (0.56) | NPC1RAB9AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929107-A | INHIBITORS OF ACYL-COA:CHOLESTEROL ACYLTRANSFERASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-27 | — | — | US | disclosed |
| US-5492929-A | ENZYME INHIBITORS, ANTICHOLESTEROL AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-20 | — | — | US | disclosed |
| EP-0602598-A1 | 3-Phenylindolyl-, -benzofuranyl- and -benzothienyl- alkylcarboxanilides, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0117675-B1 | BENZOFURAN AND BENZOTHIOPHENE-CARBOXYLIC-ACID DERIVATIVES | BEECHAM GROUP PLC (GB) | 1986-07-23 | — | — | EP | disclosed |
| US-4548948-A | Anti-inflammatory and analgesic benzothiophene and benzafuran derivatives, compositions, and method of use therefor | BEECHAM GROUP P.L.C. (GB) | 1985-10-22 | — | — | US | disclosed |
| EP-0117675-A1 | Benzofuran and benzothiophene-carboxylic-acid derivatives | BEECHAM GROUP PLC (GB) | 1984-09-05 | — | — | EP | disclosed |