SCHEMBL8400429

SCHEMBL8400429

O=C(Sc1ccc(Cl)cc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.55
KDM4E B2RXH2 3/20 0.55
TDP1 Q9NUW8 3/20 0.55
CYP2C9 P11712 3/20 0.55
CYP2C19 P33261 3/20 0.55
CYP1A2 P05177 2/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
CYP2D6 P10635 1/20 0.55
HPGD P15428 1/20 0.55
CES2 O00748 1/20 0.55
CES1 P23141 1/20 0.55
LMNA P02545 3/20 0.54
ALDH1A1 P00352 3/20 0.51
TERT O14746 1/20 0.47
NPSR1 Q6W5P4 2/20 0.47
NPC1 O15118 1/20 0.47
HTT P42858 1/20 0.47
RAB9A P51151 1/20 0.47
TRPA1 O75762 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8400140 0.92 CES2 (0.55) MAPTKDM4ETDP1CYP2C9CYP2C19
SCHEMBL26038959 0.89 CES1 (0.48) MAPTKDM4ETDP1CYP2C9CYP2C19
SCHEMBL274958 0.85 TTR (0.49) MAPTKDM4ETDP1CYP2C9CYP2C19
SCHEMBL10500354 0.82 MAPK1 (0.59) MAPTCYP2C19CYP1A2CYP2D6HPGD
SCHEMBL14599304 0.82 CES2 (0.54) MAPTTDP1MEN1KMT2AHPGD
SCHEMBL31054327 0.81 CES2 (0.60) MAPTKDM4ETDP1CYP2C9CYP2C19
SCHEMBL12812880 0.81 LMNA (0.54) MAPTKMT2ACES2CES1LMNA
SCHEMBL8359013 0.81 NPC1 (0.48) MAPTCYP2C9CYP1A2HPGDCES2
SCHEMBL5696801 0.80 NPC1 (0.59) MAPTKDM4ETDP1CYP2C9CYP2C19
SCHEMBL9871801 0.80 TTR (0.40) MAPTKDM4ETDP1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113372251-B Method for synthesizing thioester by cross coupling of sodium sulfinate and acyl chloride under catalysis of visible light 陕西师范大学 2023-04-14 CN disclosed
CN-113372251-A Method for synthesizing thioester by cross coupling of sodium sulfinate and acyl chloride under catalysis of visible light 陕西师范大学 2021-09-10 CN disclosed
US-5916495-A COMPRISING POLYMETHYL METHACRYLATE AND A CLADDING LAYER; VARYING REFRACTIVE INDEX SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-06-29 US disclosed
US-5891570-A Plastic optical fiber preform having a jacket layer SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-04-06 US disclosed
US-5851666-A Plastic optical fiber preform, and process and apparatus for producing the same SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1998-12-22 US disclosed
US-5639512-A REFRACTIVE INDEX GRADIENTS SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-06-17 US disclosed
US-5614253-A DEPOSITING POLYMER LAYER WITH REFRACTIVE INDEX MODIFIER SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-03-25 US disclosed
EP-0664463-A1 PLASTIC OPTICAL FIBER BASE MATERIAL, PRODUCTION METHOD THEREFOR, AND APPARATUS THEREFOR SUMITOMO ELECTRIC INDUSTRIES, LIMITED (JP) 1995-07-26 EP disclosed
EP-0662620-A1 PRODUCTION METHOD AND APPARATUS FOR PLASTIC OPTICAL FIBER BASE MATERIAL SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1995-07-12 EP disclosed