Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | DRD3 | P35462 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.42 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.42 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396403 | 0.96 | MEN1 (0.49) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL8399088 | 0.92 | HTR1A (0.48) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL8398992 | 0.92 | DRD2 (0.44) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL8400124 | 0.90 | DRD2 (0.43) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL8395281 | 0.89 | DRD2 (0.42) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| SCHEMBL8400527 | 0.88 | HTR1A (0.50) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| SCHEMBL8400183 | 0.88 | DRD2 (0.43) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL8397820 | 0.87 | HTR1A (0.60) | DRD2DRD3HTR1A | |
| SCHEMBL7883032 | 0.87 | CCR1 (0.48) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| SCHEMBL8793314 | 0.87 | HTR1A (0.46) | DRD2DRD3ALDH1A1KMT2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |