Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.49 |
| ▸ | POLA1 | P09884 | 2/20 | 0.46 |
| ▸ | POLG | P54098 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8400861 | 0.90 | HSP90AB1 (0.45) | FGFR1SLC22A6POLA1POLGABCB11 | |
| SCHEMBL8400651 | 0.89 | CDK1 (0.53) | CDK1CCNB1CCNE1CDK2FGFR1 | |
| SCHEMBL30030144 | 0.86 | FGFR1 (0.68) | FGFR1SLC22A6POLA1POLGABCB11 | |
| SCHEMBL8397101 | 0.86 | FGFR1 (0.68) | FGFR1SLC22A6POLA1POLGABCB11 | |
| SCHEMBL2734810 | 0.82 | FGFR1 (0.59) | CDK1CCNB1CCNE1CDK2FGFR1 | |
| Pmedap SCHEMBL215611 | 0.82 | FGFR1 (0.72) | CDK1CCNB1CCNE1CDK2FGFR1 | |
| Pmedap SCHEMBL29571667 | 0.82 | FGFR1 (0.72) | CDK1CCNB1CCNE1CDK2FGFR1 | |
| SCHEMBL24721834 | 0.79 | FGFR1 (0.56) | CDK1CCNB1CCNE1CDK2FGFR1 | |
| SCHEMBL8400863 | 0.79 | SLC22A6 (0.47) | FGFR1SLC22A6POLA1POLGABCB11 | |
| SCHEMBL19929316 | 0.79 | SLC22A6 (0.45) | CDK1CCNB1CCNE1CDK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874577-A | Method for the preparing 9-12-(Diethoxyphosphonomethoxy)ethyl!adenine and analogues thereof | MEDICHEM RESEARCH, INC. (US) | 1999-02-23 | — | — | US | disclosed |