Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 0.52 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039642 | 0.84 | LCK (0.54) | LCKSRCLYNBTK | |
| SCHEMBL4036713 | 0.83 | LCK (0.55) | LCKSRC | |
| SCHEMBL4036352 | 0.81 | LCK (0.51) | LCKSRCLYNBTK | |
| SCHEMBL4038784 | 0.81 | LCK (0.51) | LCKSRCLYNBTK | |
| SCHEMBL4036241 | 0.81 | LCK (0.51) | LCKSRCLYNBTK | |
| SCHEMBL4040544 | 0.80 | LCK (0.50) | LCKSRCLYNBTK | |
| SCHEMBL8400908 | 0.80 | LCK (0.52) | LCKSRC | |
| SCHEMBL4037815 | 0.79 | LCK (0.48) | LCKSRCLYNBTK | |
| SCHEMBL4039029 | 0.78 | LCK (0.59) | LCKSRC | |
| SCHEMBL4045069 | 0.78 | LCK (0.52) | LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990109-A | NOVEL COMPOUNDS, METHODS OF THEIR SYNTHESIS, AND THEIR USE IN TREATING VARIOUS TYROSINE KINASE-ASSOCIATED IMMUNOLOGICAL DISORDERS, SUCH AS RHEUMATOID ARTHRITIS, MULTIPLE SCLEROSIS, GRAFT VS. HOST DISEASE, LUPUS, PSORIASIS AND ASTHMA | BRISTOL-MYERS SQUIBB CO. (US) | 1999-11-23 | — | — | US | disclosed |