Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529535 | 0.92 | ADORA2B (0.76) | ADORA2BLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL14520056 | 0.84 | ADORA2B (0.61) | ADORA2BLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL14520057 | 0.81 | ADORA2B (0.57) | ADORA2BLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL11018328 | 0.80 | ADORA2B (0.70) | ADORA2BLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL17633964 | 0.80 | ADORA2B (0.70) | ADORA2BLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL10354149 | 0.79 | ADORA2B (0.68) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL316279 | 0.79 | ADORA2B (1.00) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL19370573 | 0.78 | ADORA2B (0.71) | ADORA2BLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL16120984 | 0.78 | ADORA2B (0.81) | ADORA2BLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL660023 | 0.78 | ADORA2B (0.76) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958933-A | HAVING A GUANIDINO GROUP ALIPHATICALLY LINKED TO A XANTHINE GROUP, ADRENERGIC STIMULANTS | NAFTCHI N ERIC (US) | 1999-09-28 | — | — | US | disclosed |