Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.58 |
| ▸ | MC3R | P41968 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.58 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.58 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL8400928 | 0.92 | ADORA2B (0.65) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL316279 | 0.86 | ADORA2B (1.00) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL10354149 | 0.86 | ADORA2B (0.68) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL19370573 | 0.85 | ADORA2B (0.71) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL16120984 | 0.85 | ADORA2B (0.81) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL11430966 | 0.84 | ADORA2B (0.70) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL11018328 | 0.84 | ADORA2B (0.70) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL17633964 | 0.84 | ADORA2B (0.70) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL15453218 | 0.84 | ADORA2B (0.72) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL19533057 | 0.83 | ADORA2B (0.73) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114264730-A | Method for detecting related substances of doxofylline injection | 扬子江药业集团南京海陵药业有限公司 | 2022-04-01 | — | — | CN | claimed |
| CN-111060623-A | Method for detecting doxofylline impurities | 北京鑫开元医药科技有限公司 | 2020-04-24 | — | — | CN | claimed |
| EP-0272596-B1 | Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included | ABC IST BIOLOG CHEM SPA (IT) | 1994-03-09 | — | — | EP | claimed |
| EP-0272596-A2 | Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included | ISTITUTO BIOLOGICO CHEMIOTERAPICO "ABC" S.p.A. (IT) | 1988-06-29 | — | — | EP | claimed |
| CN-114264730-B | Method for detecting related substances of doxofylline injection | 扬子江药业集团南京海陵药业有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-114264730-A | Method for detecting related substances of doxofylline injection | 扬子江药业集团南京海陵药业有限公司 | 2022-04-01 | — | — | CN | disclosed |
| US-10703754-B2 | Compounds and compositions for treating chemical warfare agent-induced injuries | ELI LILLY AND COMPANY (US) | 2020-07-07 | — | — | US | disclosed |
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| CN-111060623-A | Method for detecting doxofylline impurities | 北京鑫开元医药科技有限公司 | 2020-04-24 | — | — | CN | disclosed |
| US-20190194202-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES | ELI LILLY AND COMPANY | 2019-06-27 | — | — | US | disclosed |
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | ELI LILLY AND COMPANY | 2018-05-17 | — | — | US | disclosed |
| US-9951073-B2 | Compounds and compositions for treating chemical warfare agent-induced injuries | HYDRA BIOSCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-4960773-A | ANTITUSSIVE AGENT | CHINOIN GYOGYSZER- ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1990-10-02 | — | — | US | disclosed |
| EP-0177659-B1 | ESTER DERIVATIVES OF 7-(OMEGA-OXYALKYL) THEOPHYLLINE AND THEIR PHARMACEUTICAL ACTIVITY | Medosan Industrie Biochimiche Riunite S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |
| US-4868186-A | BRONCHODILATOR AGENTS | ISTITUTO BIOLOGICO CHEMIOTERAPICO ABC S.P.A. (JP) | 1989-09-19 | — | — | US | disclosed |
| EP-0315401-A2 | Xanthine derivatives and their preparation and pharmaceutical formulation | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-05-10 | — | — | EP | disclosed |
| EP-0272596-A2 | Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included | ISTITUTO BIOLOGICO CHEMIOTERAPICO "ABC" S.p.A. (IT) | 1988-06-29 | — | — | EP | disclosed |
| EP-0089028-B1 | THEOPHYLLIN DERIVATIVES, AND PROCESS FOR THEIR PREPARATION | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1988-05-25 | — | — | EP | disclosed |
| US-4618612-A | ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, BRONCHODILATOR AGENTS | MEDOSAN INDUSTRIE BIOCHIMICHE RIUNITE S.P.A. (IT) | 1986-10-21 | — | — | US | disclosed |
| EP-0177659-A1 | Ester derivatives of 7-(omega-oxyalkyl) theophylline and their pharmaceutical activity | Medosan Industrie Biochimiche Riunite S.p.A. (IT) | 1986-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703754-B2 | Compounds and compositions for treating chemical warfare agent-induced injuries | ELANE, CASP3, MMP8 | ADORA2B 1599/4885LMNA 594/4885MAPT 2844/4885 |
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | ADORA2B 176/4885LMNA 819/4885MAPT 568/4885 |
| US-20190194202-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES | ELANE, CASP3, MMP8 | ADORA2B 1599/4885LMNA 594/4885MAPT 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.