Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TK1 | P04183 | 4/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9652156 | 0.78 | TK1 (0.43) | TK1DHFR | |
| SCHEMBL7255448 | 0.78 | TK1 (0.43) | TK1DHFR | |
| SCHEMBL8403656 | 0.73 | ALDH1A1 (0.56) | ALDH1A1LMNAALBPOLBADRA1A | |
| SCHEMBL7049183 | 0.70 | ALDH1A1 (0.41) | ALDH1A1LMNAALBPOLBADRA1A | |
| SCHEMBL8510407 | 0.70 | TK1 (0.60) | TK1DHFR | |
| SCHEMBL2108282 | 0.69 | ALDH1A1 (0.43) | ALDH1A1LMNAALBPOLBADRA1A | |
| SCHEMBL2108286 | 0.69 | ALDH1A1 (0.43) | ALDH1A1LMNAALBPOLBADRA1A | |
| SCHEMBL9011728 | 0.69 | TK1 (0.50) | TK1DHFR | |
| SCHEMBL9011727 | 0.69 | TK1 (0.50) | TK1DHFR | |
| SCHEMBL800959 | 0.68 | ALDH1A1 (0.43) | ALDH1A1LMNAALBPOLBADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0735044-B1 | Preparation of D4T from 5-methyluridine | BRISTOL MYERS SQUIBB CO (US) | 1999-06-23 | — | — | EP | claimed |
| US-5608049-A | 2,3-DIDEHYDRO-3'-DEOXYTHYMIDINE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-04 | — | — | US | claimed |
| EP-0735044-A1 | Preparation of D4T from 5-methyluridine | Bristol-Myers Squibb Company (US) | 1996-10-02 | — | — | EP | claimed |
| EP-0735044-B1 | Preparation of D4T from 5-methyluridine | BRISTOL MYERS SQUIBB CO (US) | 1999-06-23 | — | — | EP | disclosed |
| EP-0653436-B1 | 5-Methyluridine process for large-scale preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) | BRISTOL MYERS SQUIBB CO (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5672698-A | BLOCKING WITH MESYL CHLORIDE; HYDROXIDE TREATMENT TO CYCLICIZE; DISPLACEMENT OF THE 5'-MESYL GROUP WITH BENZOATE AND HYDROBROMINATION; CHEMICAL REDUCTION WITH ZINC; DISSOLVING IN N-METHYLPYRROLIDONE AND BUTYLACETATE; AIDS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0653437-B1 | Process for preparing AZT and derivatives thereof | BRISTOL MYERS SQUIBB CO (US) | 1997-08-13 | — | — | EP | disclosed |
| US-5608049-A | 2,3-DIDEHYDRO-3'-DEOXYTHYMIDINE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0735044-A1 | Preparation of D4T from 5-methyluridine | Bristol-Myers Squibb Company (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5466787-A | Process for preparing AZT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0653437-A1 | Process for preparing AZT and derivatives thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-05-17 | — | — | EP | disclosed |
| EP-0653436-A1 | 5-Methyluridine process for large-scale preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-05-17 | — | — | EP | disclosed |