Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325838 | 0.82 | HRH3 (0.50) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL11681939 | 0.79 | CYP1A2 (0.52) | BCHEACHE | |
| SCHEMBL3560236 | 0.78 | ALDH1A1 (0.50) | HDAC8HDAC6LMNAALDH1A1MAPK1 | |
| SCHEMBL7768079 | 0.77 | HRH3 (0.84) | HRH3HDAC8HDAC6 | |
| SCHEMBL4471773 | 0.76 | HRH3 (0.61) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL2043393 | 0.76 | HRH3 (0.61) | HRH3HDAC8HDAC6LMNAALDH1A1 | |
| SCHEMBL11681954 | 0.76 | CYP1A2 (0.56) | BCHEACHE | |
| SCHEMBL5191611 | 0.75 | ALDH1A1 (0.46) | LMNAALDH1A1 | |
| SCHEMBL8401340 | 0.74 | HRH3 (0.53) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL6664376 | 0.74 | ALDH1A1 (0.50) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981500-A | Antiparasitic agents related to the milbemycins and avermectins | PFIZER INC. (US) | 1999-11-09 | — | — | US | claimed |
| EP-0677054-A1 | NEW ANTIPARASITIC AGENTS RELATED TO THE MILBEMYCINS AND AVERMECTINS | PFIZER INC. (US) | 1995-10-18 | — | — | EP | claimed |
| WO-1994015944-A1 | NEW ANTIPARASITIC AGENTS RELATED TO THE MILBEMYCINS AND AVERMECTINS | PFIZER LIMITED (GB) | 1994-07-21 | — | — | WO | claimed |