Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325843 | 0.79 | HRH3 (0.50) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL3560235 | 0.78 | HPGD (0.46) | HDAC8HDAC6 | |
| SCHEMBL7768079 | 0.77 | HRH3 (0.84) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL4471773 | 0.76 | HRH3 (0.61) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL224555 | 0.75 | MAPT (0.55) | HDAC8HDAC6CNR2 | |
| SCHEMBL6412394 | 0.75 | HRH3 (0.59) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL5191602 | 0.75 | PLK1 (0.44) | — | |
| SCHEMBL8401345 | 0.74 | HRH3 (0.53) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL6664372 | 0.74 | TRPA1 (0.39) | — | |
| SCHEMBL5925786 | 0.73 | HRH3 (0.70) | HRH3HDAC8HDAC6PYCR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981500-A | Antiparasitic agents related to the milbemycins and avermectins | PFIZER INC. (US) | 1999-11-09 | — | — | US | claimed |
| EP-0677054-A1 | NEW ANTIPARASITIC AGENTS RELATED TO THE MILBEMYCINS AND AVERMECTINS | PFIZER INC. (US) | 1995-10-18 | — | — | EP | claimed |
| WO-1994015944-A1 | NEW ANTIPARASITIC AGENTS RELATED TO THE MILBEMYCINS AND AVERMECTINS | PFIZER LIMITED (GB) | 1994-07-21 | — | — | WO | claimed |