Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405271 | 0.81 | NPC1 (0.53) | NPC1RAB9AELANEL3MBTL1ALDH1A1 | |
| SCHEMBL4019038 | 0.80 | NPC1 (0.58) | NPC1RAB9AELANECASP3FAAH | |
| SCHEMBL8401418 | 0.78 | NPC1 (0.51) | NPC1RAB9AELANEL3MBTL1ALDH1A1 | |
| SCHEMBL4019341 | 0.76 | NPC1 (0.52) | NPC1RAB9AELANECASP3FAAH | |
| SCHEMBL4027749 | 0.74 | TNKS (0.51) | NPC1RAB9AELANECASP3TNKS | |
| SCHEMBL7410978 | 0.74 | ELANE (0.45) | NPC1RAB9AELANECASP3MGLL | |
| SCHEMBL7297119 | 0.73 | NPC1 (0.48) | NPC1RAB9AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL7434551 | 0.72 | NPC1 (0.48) | NPC1RAB9AELANECASP3POLB | |
| SCHEMBL8405738 | 0.72 | NPC1 (0.48) | NPC1RAB9AELANECASP3TNKS | |
| SCHEMBL7333977 | 0.72 | NPC1 (0.46) | NPC1RAB9AELANECASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |