Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019341 | 0.85 | NPC1 (0.52) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL4027749 | 0.84 | TNKS (0.51) | NPC1RAB9ACASP3POLBROCK2 | |
| SCHEMBL7297119 | 0.82 | NPC1 (0.48) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL7434551 | 0.82 | NPC1 (0.48) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL8405738 | 0.81 | NPC1 (0.48) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL4416727 | 0.81 | NPC1 (0.62) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL8405271 | 0.81 | NPC1 (0.53) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL8401492 | 0.81 | NPC1 (0.47) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL8401415 | 0.80 | NPC1 (0.52) | NPC1RAB9ACASP3POLBSMN1; SMN2 | |
| SCHEMBL8404944 | 0.79 | NPC1 (0.46) | NPC1RAB9ACASP3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137803-A1 | 5-PROTECTED AMINOPYRIMIDINE COMPOUND, PRODUCTION METHOD THEREOF AND INTERMEDIATE THEREFOR | AJINOMOTO CO., INC. (JP) | 2009-05-28 | — | — | US | claimed |
| US-20050209257-A1 | 5-Protected aminopyrimidine compound, production method thereof and intermediate therefor | AJINOMOTO CO., INC. (JP) | 2005-09-22 | — | — | US | claimed |
| EP-1577303-A1 | 5-protected aminopyrimidine compound, production method thereof and intermediate thereof | Ajinomoto Co., Inc. (JP) | 2005-09-21 | — | — | EP | claimed |
| US-20090137803-A1 | 5-PROTECTED AMINOPYRIMIDINE COMPOUND, PRODUCTION METHOD THEREOF AND INTERMEDIATE THEREFOR | AJINOMOTO CO., INC. (JP) | 2009-05-28 | — | — | US | disclosed |
| US-7507738-B2 | 5-protected aminopyrimidine compound, production method thereof and intermediate therefor | AJINOMOTO CO., INC. (JP) | 2009-03-24 | — | — | US | disclosed |
| US-20050209257-A1 | 5-Protected aminopyrimidine compound, production method thereof and intermediate therefor | AJINOMOTO CO., INC. (JP) | 2005-09-22 | — | — | US | disclosed |
| EP-1577303-A1 | 5-protected aminopyrimidine compound, production method thereof and intermediate thereof | Ajinomoto Co., Inc. (JP) | 2005-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209257-A1 | 5-Protected aminopyrimidine compound, production method thereof and intermediate therefor | DPYD, DHPS, DHFR | NPC1 4498/4885RAB9A 3465/4885CASP3 3266/4885 |
| US-20090137803-A1 | 5-PROTECTED AMINOPYRIMIDINE COMPOUND, PRODUCTION METHOD THEREOF AND INTERMEDIATE THEREFOR | DPYD, DHPS, DHFR | NPC1 4498/4885RAB9A 3465/4885CASP3 3266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.