Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 8/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405275 | 0.80 | NPC1 (0.53) | NPC1RAB9AELANEPOLBFAAH | |
| SCHEMBL6805631 | 0.78 | POLB (0.48) | NPC1RAB9AELANEPOLBMGLL | |
| SCHEMBL8401415 | 0.78 | NPC1 (0.52) | NPC1RAB9AELANEPOLBFAAH | |
| SCHEMBL7333984 | 0.77 | ELANE (0.45) | NPC1RAB9AELANEPOLBMAP3K5 | |
| SCHEMBL8519576 | 0.76 | NPC1 (0.45) | NPC1RAB9AELANEPOLBMGLL | |
| SCHEMBL7297125 | 0.76 | NPC1 (0.44) | NPC1RAB9AELANEPOLBFAAH | |
| SCHEMBL7294381 | 0.76 | ELANE (0.47) | NPC1RAB9AELANEPOLBMGLL | |
| SCHEMBL7292939 | 0.74 | ELANE (0.46) | NPC1RAB9AELANEPOLBMGLL | |
| SCHEMBL7297829 | 0.74 | NAMPT (0.48) | NPC1RAB9AELANEPOLBP4HTM | |
| SCHEMBL27467966 | 0.73 | NPC1 (0.50) | NPC1RAB9AELANEPOLBFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |