Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13164724 | 0.86 | LMNA (0.46) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL24212836 | 0.82 | LMNA (0.43) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL23471142 | 0.80 | MAPT (0.38) | SMN1; SMN2LMNAL3MBTL1ALDH1A1GAA | |
| SCHEMBL8404981 | 0.80 | GAA (0.46) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL19782337 | 0.79 | MEN1 (0.46) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL14458150 | 0.78 | MAPK1 (0.44) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL11978610 | 0.78 | LMNA (0.41) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL24642948 | 0.78 | LMNA (0.41) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9125092 | 0.78 | TSHR (0.41) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL13184561 | 0.78 | LMNA (0.41) | SMN1; SMN2MAPK1LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293530-A1 | SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | METHYLGENE INC. (CA) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293530-A1 | SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HAT1 | SMN1; SMN2 2323/4885MAPK1 2651/4885LMNA 2203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.