Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.66 |
| ▸ | PTGES | O14684 | 3/20 | 0.64 |
| ▸ | TOP2A | P11388 | 1/20 | 0.64 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.64 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8400549 | 1.00 | PTPN1 (0.66) | PTPN1PTGESTOP2ANR1H2NR1H3 | |
| SCHEMBL8750720 | 0.99 | PTGES (0.66) | PTPN1PTGESTOP2ANR1H2NR1H3 | |
| SCHEMBL29979434 | 0.99 | PTGES (0.66) | PTPN1PTGESTOP2ANR1H2NR1H3 | |
| SCHEMBL19409973 | 0.88 | NR1H2 (0.72) | PTPN1PTGESTOP2ANR1H2NR1H3 | |
| SCHEMBL9396779 | 0.87 | PTPN1 (0.53) | PTPN1PTGESTOP2ANR1H2NR1H3 | |
| SCHEMBL29266100 | 0.86 | NR1H2 (0.59) | PTPN1PTGESTOP2ANR1H2NR1H3 | |
| SCHEMBL2762730 | 0.85 | PTGES (0.67) | PTPN1PTGESTOP2ATDP1CYP3A4 | |
| SCHEMBL29683894 | 0.85 | PTGES (0.67) | PTPN1PTGESTOP2ATDP1CYP3A4 | |
| SCHEMBL18051739 | 0.84 | PTPN1 (0.57) | PTPN1PTGESTOP2ANR1H2NR1H3 | |
| SCHEMBL9150312 | 0.84 | PTGES (0.60) | PTPN1PTGESTOP2ATDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859067-A | PREPARING BIS(2-HYDROXY-1-NAPHTHYL)DECANE FROM THE CORRESPONDING DIACID; FORMING ACID DICHLORIDE; TREATING WITH 2-NAPHTHOL; REARRANGEMENT; REDUCTION; INHIBITS ACTION OF ADENOSINE TRIPHOSPHATASE | ROUFOGALIS BASIL DON (AU) | 1999-01-12 | — | — | US | disclosed |
| US-5741821-A | PHENOLIC ENZYME INHIBITORS | THE UNIVERSITY OF SYDNEY (AU) | 1998-04-21 | — | — | US | disclosed |
| EP-0703780-A4 | USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | UNIV SYDNEY (AU) | 1998-01-07 | — | — | EP | disclosed |
| CN-1124922-A | Use of natural products and related synthetic compounds for the treatment of cardiovascular diseases | UNIV SYDNEY (AU) | 1996-06-19 | — | — | CN | disclosed |
| EP-0703780-A1 | USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | THE UNIVERSITY OF SYDNEY (AU) | 1996-04-03 | — | — | EP | disclosed |