Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20766453 | 0.88 | SLC7A5 (0.50) | SLC7A5SMN1; SMN2LMNAPOLBPLA2G4B | |
| SCHEMBL10865828 | 0.88 | ALDH1A1 (0.50) | SLC7A5LMNAPLA2G4BGAAPPARG | |
| SCHEMBL2767480 | 0.84 | SMN1; SMN2 (0.53) | SLC7A5SMN1; SMN2GAAPPARGPPARA | |
| SCHEMBL13178572 | 0.83 | SLC7A5 (0.50) | SLC7A5SMN1; SMN2POLBGAAALDH1A1 | |
| SCHEMBL14987498 | 0.83 | SLC7A5 (0.45) | SLC7A5SMN1; SMN2LMNAPOLBPLA2G4B | |
| SCHEMBL31249652 | 0.82 | SMN1; SMN2 (0.61) | SLC7A5SMN1; SMN2POLBALDH1A1CYP1A2 | |
| SCHEMBL378705 | 0.82 | SMN1; SMN2 (0.61) | SLC7A5SMN1; SMN2POLBALDH1A1CYP1A2 | |
| SCHEMBL8355226 | 0.82 | PLA2G4B (0.57) | LMNAPLA2G4BGAAPPARGPPARA | |
| SCHEMBL3334714 | 0.82 | ALDH1A1 (0.51) | SLC7A5SMN1; SMN2PLA2G4BGAAALDH1A1 | |
| SCHEMBL28588436 | 0.82 | KMT2A (0.55) | SLC7A5SMN1; SMN2LMNAPLA2G4BGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977374-A | 5-(4-hydroxy-OR 4-acetoxy-benzyl)-3- triphenylmethylthiazolidine-2,4-dione and method for producing same | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5635534-A | 1-PHENYL-2-(2-PHENYLOXY OR THIO)-1-METHYLETHYL)AMINOETHANOL DERIVATIVES; ALDOSE REDUCTASE INHIBITORS; NONTOXIC; ANTIDIABETIC,-OBESITY,-LIPEMIC AND HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-06-03 | — | — | US | disclosed |
| CN-1034497-C | Process for the preparation of aromatic aminoalcohol derivatives useful for the treatment of diabetes and obesity | SANKYO CO (JP) | 1997-04-09 | — | — | CN | disclosed |
| US-5576340-A | Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0543662-B1 | Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | SANKYO CO (JP) | 1996-09-18 | — | — | EP | disclosed |
| CN-1073428-A | Aromatic amino alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-06-23 | — | — | CN | disclosed |
| EP-0543662-A2 | Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1993-05-26 | — | — | EP | disclosed |