Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.39 |
| ▸ | FEN1 | P39748 | 4/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841569 | 0.96 | AGTR1 (0.43) | AGTR1MMEAGTR2ALOX5APFEN1 | |
| SCHEMBL840753 | 0.94 | AGTR1 (0.41) | AGTR1MMEAGTR2ALOX5APFEN1 | |
| SCHEMBL840749 | 0.91 | AGTR1 (0.38) | AGTR1AGTR2ALOX5APFEN1LTB4R2 | |
| SCHEMBL840748 | 0.91 | AGTR1 (0.38) | AGTR1AGTR2ALOX5APFEN1LTB4R2 | |
| SCHEMBL839440 | 0.91 | AGTR1 (0.41) | AGTR1MMEAGTR2ALOX5APFEN1 | |
| SCHEMBL839441 | 0.91 | AGTR1 (0.41) | AGTR1MMEAGTR2ALOX5APFEN1 | |
| SCHEMBL840963 | 0.89 | AGTR1 (0.43) | AGTR1MMEAGTR2LTB4R2 | |
| SCHEMBL839970 | 0.89 | AGTR1 (0.42) | AGTR1MMEAGTR2LTB4R2 | |
| SCHEMBL841635 | 0.87 | AGTR1 (0.38) | AGTR1AGTR2ALOX5APFEN1LTB4R2 | |
| SCHEMBL841636 | 0.87 | AGTR1 (0.38) | AGTR1AGTR2ALOX5APFEN1LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |