Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 8/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841556 | 0.95 | LTB4R2 (0.42) | AGTR1AGTR2MMELTB4R2 | |
| SCHEMBL839509 | 0.93 | AGTR1 (0.43) | AGTR1AGTR2MMELTB4R2OPRM1 | |
| SCHEMBL841734 | 0.90 | AGTR1 (0.46) | AGTR1AGTR2MMELTB4R2 | |
| SCHEMBL841733 | 0.90 | AGTR1 (0.46) | AGTR1AGTR2MMELTB4R2 | |
| SCHEMBL840212 | 0.89 | AGTR1 (0.36) | AGTR1AGTR2MME | |
| SCHEMBL840307 | 0.89 | AGTR1 (0.41) | AGTR1AGTR2MMELTB4R2 | |
| SCHEMBL840866 | 0.88 | AGTR1 (0.43) | AGTR1AGTR2MMELTB4R2 | |
| SCHEMBL839461 | 0.87 | AGTR1 (0.43) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL839460 | 0.87 | AGTR1 (0.43) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL859395 | 0.86 | LTB4R2 (0.47) | AGTR1AGTR2MMELTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |